Urine test for autism may be on the horizon

[الصحفي الطائر]

Urine test for autism may be on the horizon

Researchers may be able to develop a noninvasive urine test for autism after finding that the urine of children with autism has a different metabolic composition from those who are not diagnosed with the disorder, according to recent study data.
Researchers from the Imperial College London and the University of South Australia collected urine samples of children with autism, their siblings and those who did not have the disorder aged 3 to 9 years from the Australian site. The researchers then compared the specimens with those gathered from a group of controls, recruited from the Swiss Tropical Institute in Basel. Study participants included 39 children with autism, 28 siblings and 34 controls.
Results indicated that children with autism showed subtle differences in urinary succinate, N-methyl nicotinic acid and N-methylnicotinamide when compared with controls. Projection latent structure discriminant analysis with UV-scaled spectral data also suggested clear disparities between children with autism and the controls and some differences between those with autism (http://www.pediatricsupersite.com/searchResults.aspx?q=autism&x=0&y=0&cx=&site=Srch_Ped-SS&client=default_frontend&output=xml_no_dtd&proxystylesheet=default_frontend&filter=0&sort=date%3AD%3AS%3Ad1&siteurl=www.pediatricsupersite.com%2F) and their siblings.

[الصحفي الطائر]

Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls

Ivan K. S. Yap† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1), Manya Angley† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1)‡ (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn2), Kirill A. Veselkov† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1), Elaine Holmes† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1), John C. Lindon† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1) and Jeremy K. Nicholson* (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#cor1)† (http://pubs.acs.org/doi/pdf/10.1021/pr901188e#afn1)
Biomolecular Medicine, Division of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, United Kingdom, and Sansom Institute, Division of Health Sciences, University of South Australia
J. Proteome Res., 2010, 9 (6), pp 2996–3004
DOI: 10.1021/pr901188e
Publication Date (Web): March 25, 2010
Copyright © 2010 American Chemical Society

[الصحفي الطائر]

Abstract

Autism is an early onset developmental disorder with a severe life-long impact on behavior and social functioning that has associated metabolic abnormalities. The urinary metabolic phenotypes of individuals (age range=3−9 years old) diagnosed with autism using the DSM-IV-TR criteria (n = 39; male = 35; female = 4), together with their nonautistic siblings (n = 28; male = 14; female = 14) and age-matched healthy volunteers (n = 34, male = 17; female = 17) have been characterized for the first time using 1H NMR spectroscopy and pattern recognition methods. Novel findings associated with alterations in nicotinic acid metabolism within autistic individuals showing increased urinary excretion of N-methyl-2-pyridone-5-carboxamide, N-methyl nicotinic acid, and N-methyl nicotinamide indicate a perturbation in the tryptophan−nicotinic acid metabolic pathway. Multivariate statistical analysis indicated urinary patterns of the free amino acids, glutamate and taurine were significantly different between groups with the autistic children showing higher levels of urinary taurine and a lower level of urinary glutamate, indicating perturbation in sulfur and amino acid metabolism in these children. Additionally, metabolic phenotype (metabotype) differences were observed between autistic and control children, which were associated with perturbations in the relative patterns of urinary mammalian-microbial cometabolites including dimethylamine, hippurate, and phenyacetylglutamine. These biochemical changes are consistent with some of the known abnormalities of gut microbiota found in autistic individuals and the associated gastrointestinal dysfunction and may be of value in monitoring the success of therapeutic interventions.

[تعب !]

انا ثقافتي فرنسي
ترجم لو سمحت